There are many things that can bother you. However, it all comes down to a few simple issues.
1. Will this issue affect my ability to react to future issues, if so, in a positive or negative way.
2. Will my reaction cause problems, either immediately, or later on, for my ability to evaluate my options in regards to reacting to any given issue?
Understanding these, and then understanding how they directly govern how you respond to any situation, will enable to predict most logical actions for most people. However, it can also be summed in a single statement, made in the old SPQR. "Qui Bono?" Who profits?..